منابع مشابه
HaploBlockFinder: Haplotype Block Analyses
UNLABELLED Recent studies have unveiled discrete block-like structures of linkage disequilibrium (LD) in the human genome. We have developed a set of computer programs to analyze the block-like LD structures (haplotype blocks) based on haplotype data. Three definitions of haplotype block are supported, including minimal LD range, no historic recombination, and chromosome coverage. Tagged SNPs t...
متن کاملRobustness of Inference of Haplotype Block Structure
In this report, we examine the validity of the haplotype block concept by comparing block decompositions derived from public data sets by variants of several leading methods of block detection. We first develop a statistical method for assessing the concordance of two block decompositions. We then assess the robustness of inferred haplotype blocks to the specific detection method chosen, to arb...
متن کاملHaplotype Block Detection Using Cira Pattern Discovery
This note reports on a novel method of detection of haplotype blocks in the human genome. It is based upon pattern discovery using technology being patented by Cira Discovery Sciences, Inc. It is intended as a demonstration of our pattern discovery technology in the context of genomic variation (SNP) data. Actual applications in genomic analyses will take advantage of technological advances tha...
متن کاملAlgorithms for Haplotype Inference and Block Partitioning
The completion of the human genome project in 2003 paved the way for studies to better understand and catalog variation in the human genome. The International HapMap Project was started in 2002 with the aim of identifying genetic variation in the human genome and studying the distribution of genetic variation across populations of individuals. The information collected by the HapMap project wil...
متن کاملRelaxing Haplotype Block Models for Association Testing
The arrival of publicly available genome-wide variation data is creating new opportunities for reconciling model-based methods for associating genotypes and phenotypes with the complexities of real genome data. Such data is particularly valuable for testing the utility of models of conserved haplotype structure to association studies. While there is much interest in "haplotype block" models tha...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2003
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg142